American Podiatric Medical Licensing Examination (APMLE) Part 1 Practice Test

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Which statement about tetracyclines is true?

They are bactericidal

They are best absorbed with dairy products

They have no effect on teeth

They cause dental enamel dysplasia and tooth discoloration in children

Tetracyclines accumulate in calcifying tissues, so they can cause enamel dysplasia and permanent tooth discoloration in children when taken during tooth development. This is why the statement about dental enamel dysplasia and tooth discoloration in children is true. In addition, these drugs are generally bacteriostatic, not bactericidal, which explains why the claim of killing bacteria is not correct. Tetracyclines are not best absorbed with dairy products because calcium in dairy chelates the drug and reduces its absorption. And since they affect developing teeth, the idea that they have no effect on teeth is incorrect.